By National Research Council, Division on Earth and Life Studies, Commission on Life Sciences, Board on Toxicology and Environmental Health Hazards, Committee on Toxicology
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Extra resources for Emergency and Continuous Exposure Limits for Selected Airborne Contaminants: volume 1
Edgewood Arsenal, Aberdeen Proving Ground, Maryland. S. 1975. Acute acetone intoxication: Case history. Occup. Health 27:120-124. S. 1973. Acute acetone intoxication involving eight male workers. Ann. Occup. Hyg. 16:73-75. R. 1973. Enhanced hepatic microsomal activity by pretreatment of rats with acetone or isopropanol. Proc. Soc. Exp. Biol. Med. 142: 237-240. R. 1944. Poisoning and fire hazards of butanone and acetone. Ind. Bull. Y. State Dept. Labor) 23:173-176. Societa Italiana di Medicina del Lavoro.
Jpn. J. Ind. Health 15:147-164. Z. 1968. S. R. Literature on Air Pollution and Related Occupational Diseases - Volume 17: The Biological Effects and Hygienic Importance of Atmospheric Pollutants: Book 10. C. p. 108-117. , and Zurlo, N. 1955. Experiences of the Clinica del Lavoro with some maximum concentrations of poisons of industry at the place of work. Transl. from: Arch. Gewerbepathol. Gewerbehyg. 13: 528-534. S. 1928. A comparison of the pharmacological actions of diacetone alcohol and acetone.
There were nonspecific inflammatory changes in lung, liver, and kidney. Squamous metaplasia of the trachea occurred in dogs and monkeys. There was necrotizing bronchitis with squamous metaplasia of the lungs in 7 of 9 monkeys. 23 ppm (continuous exposure): All animals appeared normal throughout, except one monkey that developed infection over one eye in the fifth week and died in the sixth week. Sections from 2 of 4 dogs showed moderate emphysema, acute congestion, and hemorrhage; the other 2 showed thyroid hyperplasia.